T Lymphocytes, Multi-Omic Interactions and Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) remains a significant clinical challenge in neonatal medicine. BPD is clearly multifactorial disease with numerous antenatal and postnatal components influencing lung development. Extremely immature infants are born the late canalicular or early saccular stage usually receive intensive care until alveolar of development, resulting varying magnitudes impairment septation, fibrosis, abnormal vascular The interactions between T lymphocytes, genome epigenome, microbiome metabolome, as well nutrition therapeutic interventions such exposure to oxygen, volutrauma, antibiotics, corticosteroids, caffeine omeprazole, play an important role pathogenesis progression. While our general understanding these thanks basic research improving, this knowledge yet be translated into comprehensive prevention management strategies for benefit preterm developing later during infancy childhood suffering from itself its sequelae. In review, we summarise existing evidence on interplay multi-omics currently used BPD, highlight avenues potential future immunology related field.